Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
The role of the GATA2 transcription factor in normal and malignant hematopoiesis
C Vicente, A Conchillo, MA García-Sánchez… - Critical reviews in …, 2012 - Elsevier
Hematopoiesis involves an elaborate regulatory network of transcription factors that
coordinates the expression of multiple downstream genes, and maintains homeostasis …
coordinates the expression of multiple downstream genes, and maintains homeostasis …
WhichTF is functionally important in your open chromatin data?
Y Tanigawa, ES Dyer, G Bejerano - PLOS Computational Biology, 2022 - journals.plos.org
We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …
Wishbone identifies bifurcating developmental trajectories from single-cell data
Recent single-cell analysis technologies offer an unprecedented opportunity to elucidate
developmental pathways. Here we present Wishbone, an algorithm for positioning single …
developmental pathways. Here we present Wishbone, an algorithm for positioning single …
Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis
Enhancers are the primary determinants of cell identity, but the regulatory components
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …
Transcriptional diversity during lineage commitment of human blood progenitors
Introduction Blood production in humans culminates in the daily release of around 1011
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv (3)(q21; q26) by activating EVI1 expression
Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice
Y Yang, YH Ahn, DL Gibbons, Y Zang… - The Journal of …, 2011 - Am Soc Clin Investig
Epithelial tumor cells transit to a mesenchymal state in response to extracellular cues, in a
process known as epithelial-to-mesenchymal transition (EMT). The precise nature of these …
process known as epithelial-to-mesenchymal transition (EMT). The precise nature of these …
Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells
M Iacovino, D Bosnakovski, H Fey, D Rux, G Bajwa… - Stem …, 2011 - academic.oup.com
Genetic modification is critically enabling for studies addressing specification and
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …
The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis
The histone acetyltransferases (HATs) of the MYST family include TIP60, HBO1,
MOZ/MORF, and MOF and function in multisubunit protein complexes. Bromodomain …
MOZ/MORF, and MOF and function in multisubunit protein complexes. Bromodomain …