Organogenesis involves dynamic regulation of gene transcription and complex
multipathway interactions. Despite our knowledge of key factors regulating various steps of …

Background Hematopoiesis is a highly orchestrated developmental process that comprises
various developmental stages of the hematopoietic stem cells (HSCs). During development …

Although multistability is an important dynamic property of a wide range of complex systems,
it is still a challenge to develop mathematical models for realising high order multistability …

Previous work has firmly established the role for both GATA4 and FOG2 in the initial global
commitment to sexual fate, but their (joint or individual) function in subsequent steps …

Chionodraco hamatus is a teleost within the suborder Notothenioidei, the members of which
are known to lack functional erythrocytes with modified hematopoiesis. Hematopoiesis is an …

Abstract In China, the traditional Chinese medicine “YiSui ShenXu Granule” has been used
for treating β-thalassemia over 20 years and known to be effective in clinic. Several purified …

Accumulating lines of clinical evidence support the emerging hypothesis that loss-of-function
mutations of GATA2 cause inherited hematopoietic diseases, including Emberger syndrome; …

Transcription factor GATA1 regulates the expression of a cluster of genes important for
hematopoietic cell differentiation toward erythroid and megakaryocytic lineages. Three …

Erythropoiesis is initiated with the transformation of multipotent hematopoietic stem cells into
committed erythroid progenitor cells in the erythroblastic islands of the bone marrow in …

Heart failure (HF)-associated anemia is common and has a poor outcome. Because bone
marrow (BM) dysfunction may contribute to HF-associated anemia, we first investigated …