Differentiation of adult hematopoietic stem and progenitor cells constantly produces the cell
types of the blood and immune system. Hematopoietic progenitors were previously defined …

Polycomb proteins are epigenetic regulators that are critical in mediating gene repression at
critical stages during development. Core and accessory proteins make up the Polycomb …

Acute anemia induces tissue hypoxia caused by the lack of oxygen delivery to tissues.
Increased erythropoiesis is necessary to compensate for the loss of erythrocytes and …

Hemoglobin switching is a developmental process involving the dynamic transcriptional
regulation of multiple globin genes. This molecular process involves multiple layer of …

Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G. & de
Massy, B.(2010) PRDM9 is a major determinant of meiotic recombination hotspots in …

Résumé GATA4 est un facteur de transcription essentiel pour le développement et la
fonction de plusieurs tissus, incluant les gonades. GATA4 est exprimé sous forme de deux …

La séquestration cytoplasmique d'Hsp70 par les chaînes d'α-globine libres est un
mécanisme clé de l'érythropoïèse inefficace des β-thalassémies majeures (β-TM) …

During animal development, cellular morphogenesis plays a fundamental role in
determining the shape and function of tissues and organs. Identifying the components that …

During animal development, cellular morphogenesis plays a fundamental role in
determining the shape and function of tissues and organs. Identifying the components that …

抄録 Gata1 遺伝子欠失マウスは卵黄嚢造血ができないため, 胎生 12.5 日までに重度の貧血
により胎生致死となる. Gata2 遺伝子欠失マウスは, 血管内皮細胞と造血幹細胞の共通祖先細胞で …