Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative
medicine owing to their ability to differentiate into any cell type in the body. After more than …

Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …

Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor
neuron degeneration and disease progression in rodent models of mutant superoxide …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Although the clinical outcomes of cell therapy trials have not met initial expectations,
emerging evidence suggests that injury-mediated tissue damage might benefit from the …

The cell biology of human neurodegenerative diseases has been difficult to study till
recently. The development of human induced pluripotent stem cell (iPSC) models has …