The members of the organic anion transporting polypeptide superfamily (OATPs) are
classified within the SLCO solute carrier family. All functionally well characterized members …

The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Organic anion transporting polypeptides (Oatps/OATPs) form a growing gene superfamily
and mediate transport of a wide spectrum of amphipathic organic solutes. Different …

It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

1. The molecular and functional characterization of transport proteins is emerging rapidly
and significant numbers of drugs have been shown to be substrates or inhibitors. The …

The central nervous system (CNS) contains important cellular barriers that maintain
homeostasis by protecting the brain from circulating toxins and through the elimination of …

The vectorial secretion of bile salts from blood into bile is a major driving force for bile
formation. The basolateral hepatocyte membrane extracts bile salts from sinusoidal blood …

▪ Abstract Recent studies have revealed the import role played by transporters in the renal
and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate …