Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Gram-negative bacteria and their complex cell envelope, which comprises an outer
membrane and an inner membrane, are an important and attractive system for studying the …

Fast water transport through carbon nanotube pores has raised the possibility to use them in
the next generation of water treatment technologies. We report that water permeability in 0.8 …

Inside cells, complex metabolic reactions are distributed across the modular compartments
of organelles,. Reactions in organelles have been recapitulated in vitro by reconstituting …

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial
pathogens which disrupt epithelial barrier function, damage cells and activate or modulate …

DNA nanotechnology allows for the creation of three-dimensional structures at nanometer
scale. Here, we use DNA to build the largest synthetic pore in a lipid membrane to date …

Post-translational modifications (PTMs) of proteins play key roles in cellular processes.
Hence, PTM identification is crucial for elucidating the mechanism of complex cellular …

The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …

Lipopolysaccharides (LPSs) are a constitutive element of the cell envelope of Gram-
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …