Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression,
contributing significantly to a diverse range of cellular processes, including apoptosis. One …

More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …

KRAS mutations are causally linked to protumor inflammation and are identified as driving
factors in tumorigenesis. Here, using multiomics data gathered from a large set of patients …

Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

Aberrant skipping of coding exons in CD19 and CD22 compromises the response to
immunotherapy in B-cell malignancies. Here, we showed that the MS4A1 gene encoding …

Transcription and splicing of pre-messenger RNA are closely coordinated, but how this
functional coupling is disrupted in human diseases remains unexplored. Using isogenic cell …

Simple Summary A major theory of cancer development is that cancer originates from a
specialised type of tumour cell called the cancer stem cell (CSC). Although CSCs comprise …

Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in
use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper …

RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …