[HTML][HTML] Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma

D Shetti, VR Mallela, W Ye, M Sharif… - Critical Reviews in …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high
morbidity and mortality rates. HCC is often detected at advanced stages leading to …

Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis

D Nie, X Tang, H Deng, X Yang, J Tao, F Xu… - Advanced …, 2024 - Wiley Online Library
Solute carrier family 27 member 5, a key enzyme in fatty acid transport and bile acid
metabolism in the liver, is frequently expressed in low quantities in patients with …

Extensive Alternative Splicing Patterns in Systemic Lupus Erythematosus Highlight Sexual Differences

D Kosmara, S Papanikolaou, C Nikolaou, G Bertsias - Cells, 2023 - mdpi.com
Substantial evidence highlights divergences in immune responses between men and
women. Women are more susceptible to autoimmunity, whereas men suffer from the more …

[HTML][HTML] METTL3-Mediated LINC00475 Alternative Splicing Promotes Glioma Progression by Inducing Mitochondrial Fission

Y Yan, A Luo, S Liu, M Cai, X Liu, X Zhang, S Zhang… - Research, 2024 - spj.science.org
Mitochondrial fission promotes glioma progression. The function and regulation
mechanisms of lncRNAs in glioma mitochondrial fission are unclear. The expression of …

The war between the immune system and the tumor-using immune biomarkers as tracers

K Yang, R Lu, J Mei, K Cao, T Zeng, Y Hua, X Huang… - Biomarker …, 2024 - Springer
Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy.
Specifically, immune-related targets can be used to predict the efficacy and side effects of …

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

L Xu, Z Shao, X Fang, Z Xin, S Zhao, H Zhang… - …, 2024 - Wiley Online Library
Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on
individuals and society. While the conventional use of immunosuppressants and disease …

Circulating tumor cell clustering modulates RNA splicing and polyadenylation to facilitate metastasis

Q Wu, Z Gu, B Shang, D Wan, Q Zhang, X Zhang, P Xie… - Cancer Letters, 2024 - Elsevier
Circulating tumor cell (CTC) clusters exhibit significantly higher metastatic potential
compared to single CTCs. However, the underlying mechanism behind this phenomenon …

Shaping Oncogenic Microenvironments: Contribution of Fibronectin

G Guerrero-Barberà, N Burday… - Frontiers in Cell and …, 2024 - frontiersin.org
The extracellular matrix (ECM) is a complex network of proteins and glycans, dynamically
remodeled and specifically tailored to the structure/function of each organ. The malignant …

Small molecules modulating RNA splicing: a review of targets and future perspectives

L Bouton, A Ecoutin, F Malard… - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In eukaryotic cells, RNA splicing is crucial for gene expression. Dysregulation of this process
can result in incorrect mRNA processing, leading to aberrant gene expression patterns …

Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

G Yang, J Cheng, J Xu, C Shen, X Lu, C He… - Journal of Translational …, 2024 - Springer
Background Clear cell renal cell carcinoma is a prototypical tumor characterized by
metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell …