Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health …

DR Knight, B Kullin, GO Androga, F Barbut, C Eckert… - MBio, 2019 - Am Soc Microbiol
Clostridioides difficile (Clostridium difficile) sequence type 11 (ST11) is well established in
production animal populations worldwide and contributes considerably to the global burden …

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

SJ Mileto, T Jardé, KO Childress… - Proceedings of the …, 2020 - National Acad Sciences
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal
gut function. While intestinal stem cells are critical for this regeneration process [RC van der …

Clostridium difficile in Asia: Opportunities for One Health Management

DA Collins, TV Riley - Tropical Medicine and Infectious Disease, 2018 - mdpi.com
Clostridium difficile is a ubiquitous spore-forming bacterium which causes toxin-mediated
diarrhoea and colitis in people whose gut microflora has been depleted by antimicrobial …

Molecular epidemiology of predominant and emerging Clostridioides difficile ribotypes

A Martínez-Meléndez, R Morfin-Otero… - Journal of …, 2020 - Elsevier
There has been an increase in the incidence and severity of Clostridioides difficile infection
(CDI) worldwide, and strategies to control, monitor, and diminish the associated morbidity …

Detection and Genomic Characterisation of Clostridioides difficile from Spinach Fields

P Marcos, P Whyte, C Burgess, D Ekhlas, D Bolton - Pathogens, 2022 - mdpi.com
Despite an increased incidence of Clostridioides difficile infections, data on the reservoirs
and dissemination routes of this bacterium are limited. This study examined the prevalence …

High prevalence of Clostridiodes diffiicle PCR ribotypes 001 and 126 in Iran

A Baghani, A Mesdaghinia, EJ Kuijper… - Scientific Reports, 2020 - nature.com
Clostridium difficile is a leading causative agent of hospital-acquired and community-
acquired diarrhea in human. This study aims to characterize the predominant C. difficile …

Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection

SJ Mileto, ML Hutton, SL Walton, A Das… - Gut …, 2022 - Taylor & Francis
Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea,
with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic …

Subtyping and antimicrobial susceptibility of Clostridium difficile PCR ribotype 078/126 isolates of human and animal origin

S Álvarez-Pérez, JL Blanco, C Harmanus… - Veterinary …, 2017 - Elsevier
The Clostridium difficile PCR ribotype complex 078/126 (RT078/126) is often involved in
human disease and is also frequently isolated from diverse animal species. The high …

The molecular characters and antibiotic resistance of Clostridioides difficile from economic animals in China

WZ Zhang, WG Li, YQ Liu, WP Gu, Q Zhang, H Li… - BMC microbiology, 2020 - Springer
Background It has been performed worldwidely to explore the potential of animals that might
be a reservoir for community associated human infections of Clostridioides difficile. Several …

Prevalence and molecular characterization of Clostridium difficile isolates from a pig slaughterhouse, pork, and humans in Taiwan

YC Wu, CM Chen, CJ Kuo, JJ Lee, PC Chen… - International journal of …, 2017 - Elsevier
Clostridium difficile causes antibiotic-associated diarrhea in both humans and animals. The
ribotype 078, predominant in food animals, is associated with community-acquired C …