It was long thought that the prototypical centrally acting antihypertensive drug clonidine
lowers sympathetic tone by activating α2-adrenoceptors in the brain stem. Supported by the …

The initial realization that agents containing an imidazoline structure may interact with a
distinct class of receptors, has led to a major class of cardiovascular agents, which now has …

In rodents, extended access to cocaine produces an escalation in cocaine self-
administration that has face and construct validity for human compulsive drug intake. Here …

Drugs acting within the autonomic nervous system are of particular interest when autonomic
abnormalities are implicated in the development and maintenance of various cardiovascular …

The methods of theoretical chemistry have been used to elucidate the molecular properties
of the substituted imidazoline and oxazoline structures, a class of potent agonists and …

2-(4, 5-Dihydro-1 H-imidazol-2-yl)-3, 4-dihydro-2 H-1, 4-benzoxazine derivatives and
tricyclic analogues with a fused additional ring on the nitrogen atom of the benzoxazine …

Abstract Introduction. The alpha-2 adrenergic (AA-2) receptor agonists and imidazolines are
common exposures in the American Association of Poison Control Centers (AAPCC) …

The role that the central sympathetic nervous system plays in the development of obesity
hypertension and insulin was evaluated by feeding dogs a high fat diet with or without …

I1-imidazoline-binding sites fulfill all essential criteria for identification as receptors,
including specificity of binding, association with physiological functions, appropriate …

BACKGROUND: Drug-associated cues can elicit stress-like responses in addicted
individuals, indicating that cue-and stress-induced drug relapse may share some neural …