Biomedical features and therapeutic potential of rosmarinic acid

S Noor, T Mohammad, MA Rub, A Raza… - Archives of Pharmacal …, 2022 - Springer
For decades, the use of secondary metabolites of various herbs has been an attractive
strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic …

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.

SM Patil, R Ramu, PS Shirahatti, C Shivamallu… - Heliyon, 2021 - cell.com
Thymus vulgaris Linn. is a medicinal and culinary herb from the Southern European region
known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and …

Therapeutic potential of rosmarinic acid: A comprehensive review

M Nadeem, M Imran, T Aslam Gondal, A Imran… - Applied Sciences, 2019 - mdpi.com
Naturally occurring food-derived active ingredients have received huge attention for their
chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) …

Rosmarinic acid–human pharmacokinetics and health benefits

M Hitl, N Kladar, N Gavarić, B Božin - Planta medica, 2021 - thieme-connect.com
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae)
plant species. It is considered responsible for a wide spectrum of biological and …

Evaluation of blood–brain barrier permeability of polyphenols, anthocyanins, and their metabolites

R Shimazu, M Anada, A Miyaguchi… - Journal of Agricultural …, 2021 - ACS Publications
Anthocyanins (ACs) are able to protect neurons against β-amyloid-induced neurotoxicity. In
this study, we evaluated blood–brain barrier (BBB) permeability of these compounds using a …

From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood–brain barrier

N Hartl, F Adams, OM Merkel - Advanced therapeutics, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …

A look beyond dietary (poly) phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

D Carregosa, C Pinto, MÁ Ávila‐Gálvez… - … reviews in food …, 2022 - Wiley Online Library
A large number of epidemiological studies have shown that consumption of fruits,
vegetables, and beverages rich in (poly) phenols promote numerous health benefits from …

Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

T Konno, EP Melo, JE Chambers, E Avezov - Cells, 2021 - mdpi.com
Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of …

FJ Mirza, S Amber, D Hassan, T Ahmed, S Zahid - Phytomedicine, 2021 - Elsevier
Background Rosmarinus officinalis, commonly known as rosemary, is a medicinal herb that
presents significant biological properties such as antimicrobial, antioxidant, anti …

[HTML][HTML] Conventional and nonconventional extraction techniques for optimal extraction processes of rosmarinic acid from six Lamiaceae plants as determined by …

B Sik, EL Hanczné, V Kapcsándi, Z Ajtony - Journal of Pharmaceutical and …, 2020 - Elsevier
The goal of this study was to improve the extraction efficiency of rosmarinic acid (RA) from
Lamiaceae herbs (lemon balm, peppermint, oregano, rosemary, sage, and thyme) using …