The human proteome contains approximately 20,000 proteins, and it is estimated that more
than 600 of them are functionally important for various types of cancers, including nearly 400 …

Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …

Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein
ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases …

Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …

During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …

Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine
triphosphatases (GTPases) with well-established activity against intracellular bacteria and …

The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second
largest source of mutation in cancer. This mutational process may be a causal driver or …