Objective—Impaired endothelial cell (EC) autophagy compromises shear stress–induced
nitric oxide (NO) generation. We determined the responsible mechanism. Approach and …

Adenine nucleotides, ADP and ATP, are coreleased from dense granules during platelet
activation, as well as from endothelial cells and damaged red blood cells following vascular …

The contractile and relaxant effects of the different P2 receptors were characterized in the rat
isolated mesenteric artery by use of extracellular nucleotides, including the stable …

Background Extracellular nucleotides acting through specific purinergic receptors play a key
role in synaptic transmission and neuromodulation. Therefore, any deregulation of purine …

In vivo effects of diadenosine polyphosphates on rat renal microcirculation. Background
Diadenosine polyphosphates (APXA) are vasoactive nucleotides that elicit effects via …

Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179 - PMC
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Brain capillary endothelial cells express a variety of nucleotide receptors, but differences
have been reported between culture models. This study reports examination of nucleotide …

Diadenosine polyphosphates (APnA) are endogenous dinucleoside molecules consisting of
two adenosine moieties linked via their 5′-ribose positions by a variable number of …

Publisher Summary The studies with novel P2 receptor agonists and antagonists point out
that the P2Y receptor in the taenia coli is different from the P2Y, receptor in turkey …

The P2Y1 receptor was the first of its kind to be cloned and identified as a metabotropic
receptor for adenine nucleotides (Webb et al., 1993). Since its discovery, many more P2Y …