[HTML][HTML] Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response
M Hashemi, MDA Paskeh, S Orouei, P Abbasi… - Biomedicine & …, 2023 - Elsevier
As a devastating disease, breast cancer has been responsible for decrease in life
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …
MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
New 1, 3, 4‐oxadiazoles linked with the 1, 2, 3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase
Abstract A series of 1, 3, 4‐oxadiazole‐1, 2, 3‐triazole hybrids bearing different
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
[HTML][HTML] In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking …
Artemisia judaica L.(Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and
antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was …
antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was …
[HTML][HTML] New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition
In the current study, we designed and synthesized a series of new quinoline derivatives 10a-
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …
Synthesis, characterization, and cytotoxicity of new spirooxindoles engrafted furan structural motif as a potential anticancer agent
MS Altowyan, SM Soliman, M Haukka… - ACS …, 2022 - ACS Publications
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are
reported. The new hybrids were achieved via [3+ 2] cycloaddition reaction as an economic …
reported. The new hybrids were achieved via [3+ 2] cycloaddition reaction as an economic …
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as …
MF El-Behairy, WH Abd-Allah, MM Khalifa… - Journal of Enzyme …, 2023 - Taylor & Francis
In this research, two novel series of dibenzo [b, f] azepines (14 candidates) were designed
and synthesised based on the rigidification principle and following the reported …
and synthesised based on the rigidification principle and following the reported …
Design, synthesis, and molecular modeling studies of a novel benzimidazole as an aromatase inhibitor
In this study, a series of novel 1, 3, 4-oxadiazole-benzimidazole derivatives were designed
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …
[HTML][HTML] Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …