Topical microbicides in HIV prevention: state of the promise

JM Baeten, CW Hendrix, SL Hillier - Annual review of medicine, 2020 - annualreviews.org
HIV topical microbicides are products with anti-HIV activity, generally incorporating a direct-
acting antiretroviral agent, that when applied to the vagina or rectum have the potential to …

Client-centered adherence counseling with adherence measurement feedback to support use of the dapivirine ring in MTN-025 (The HOPE Study)

IC Balán, R Giguere, C Lentz, BA Kutner… - AIDS and Behavior, 2021 - Springer
Fostering adherence and open communication about adherence challenges is key to
harnessing the potential of biomedical HIV prevention products. We describe the counseling …

Simplifying TREAtment and Monitoring for HIV (STREAM HIV): protocol for a randomised controlled trial of point-of-care urine tenofovir and viral load testing to …

AR Bardon, J Dorward, Y Sookrajh, F Sayed… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Substantial improvements in viral suppression among people living with HIV
(PLHIV) are needed to end the HIV epidemic, requiring extensive scale-up of low-cost HIV …

An open-label pharmacokinetic and pharmacodynamic assessment of tenofovir gel and oral emtricitabine/tenofovir disoproxil fumarate

IM McGowan, RP Kunjara Na Ayudhya… - AIDS research and …, 2022 - liebertpub.com
The Microbicide Trials Network-017 study was undertaken to characterize the safety,
acceptability, pharmacokinetic (PK), and pharmacodynamic profile of the reduced-glycerin …

Low disclosure of PrEP nonadherence and HIV-risk behaviors associated with poor HIV PrEP adherence in the HPTN 067/ADAPT study

VD Ojeda, KR Amico, JP Hughes… - JAIDS Journal of …, 2019 - journals.lww.com
Objective: We evaluated the relationship between 2 types of social relationships, ie,(1)
external support for use of HIV pre-exposure prophylaxis (PrEP) and related study supplies …

[HTML][HTML] Perspectives on the utility and interest in a point-of-care urine tenofovir test for adherence to HIV pre-exposure prophylaxis and antiretroviral therapy: an …

AR Bardon, JM Simoni, LM Layman, JD Stekler… - AIDS Research and …, 2020 - Springer
Background Real-time, objective measures of adherence to antiretroviral therapy (ART) and
pre-exposure prophylaxis (PrEP) are needed to better assess adherence levels and to …

Women's experience receiving drug feedback and adherence counseling in MTN-025/HOPE-an HIV Prevention open-label trial of the Dapivirine Vaginal Ring

AWK Katz, IC Balán, K Reddy, J Etima, K Weber… - AIDS and Behavior, 2022 - Springer
Abstract In the Phase IIIB MTN-025/HOPE open label extension trial, participants were
offered the dapivirine vaginal ring as HIV prophylaxis, and those who accepted the ring …

[HTML][HTML] Methods, system errors, and demographic differences in participant errors using daily text message-based short message service computer-assisted self …

W Brown III, A Sheinfil, J Lopez-Rios, R Giguere… - Mhealth, 2019 - ncbi.nlm.nih.gov
Background Assessment of sexual risk behavior is crucial to HIV prevention trials. Currently,
there are no biomarkers or objective measures to detect and characterize sexual risk …

Sharing objective measures of adherence to a vaginal microbicide promotes candor about actual use and bolsters motivation to prevent HIV

BA Kutner, R Giguere, C Lentz, C Kajura-Manyindo… - AIDS and Behavior, 2021 - Springer
Discrepancies between self-reported and actual adherence to biomedical HIV interventions
is common and in clinical trials can compromise the integrity of findings. One solution is to …

[HTML][HTML] Protocol: Simplifying TREAtment and Monitoring for HIV (STREAM HIV): protocol for a randomised controlled trial of point-of-care urine tenofovir and viral load …

AR Bardon, J Dorward, Y Sookrajh, F Sayed… - BMJ Open, 2021 - ncbi.nlm.nih.gov
Introduction Substantial improvements in viral suppression among people living with HIV
(PLHIV) are needed to end the HIV epidemic, requiring extensive scaleup of low-cost HIV …