Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …
New insights into modes of GPCR activation
W Wang, Y Qiao, Z Li - Trends in pharmacological sciences, 2018 - cell.com
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …
heterotrimeric G proteins on the membrane and then activate downstream signaling …
Dopamine receptor signaling
KA Neve, JK Seamans… - Journal of receptors and …, 2004 - Taylor & Francis
The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …
shared signaling properties that contribute to the definition of the receptor class, although …
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1–A2A receptor heteromers
The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …
An update on the mechanisms of the psychostimulant effects of caffeine
S Ferré - Journal of neurochemistry, 2008 - Wiley Online Library
There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …
Building a new conceptual framework for receptor heteromers
Receptor heteromers constitute a new area of research that is reshaping our thinking about
biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we …
biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we …
[HTML][HTML] Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
Spinal opioid-induced itch, a prevalent side effect of pain management, has been proposed
to result from pain inhibition. We now report that the μ-opioid receptor (MOR) isoform …
to result from pain inhibition. We now report that the μ-opioid receptor (MOR) isoform …
[HTML][HTML] Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy …
There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …
Targeting adenosine A2A receptors in Parkinson's disease
MA Schwarzschild, L Agnati, K Fuxe, JF Chen… - Trends in …, 2006 - cell.com
The adenosine A 2A receptor has emerged as an attractive non-dopaminergic target in the
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …
Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis
MP de la Mora, A Gallegos-Cari… - Progress in …, 2010 - Elsevier
Dopamine plays an important role in fear and anxiety modulating a cortical brake that the
medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an …
medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an …