Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …

The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …

Receptor heteromers constitute a new area of research that is reshaping our thinking about
biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we …

Spinal opioid-induced itch, a prevalent side effect of pain management, has been proposed
to result from pain inhibition. We now report that the μ-opioid receptor (MOR) isoform …

There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …

The adenosine A 2A receptor has emerged as an attractive non-dopaminergic target in the
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …

Dopamine plays an important role in fear and anxiety modulating a cortical brake that the
medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an …