Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Background Cerebral microhemorrhages (CMH) are associated with stroke, cognitive
decline, and normal aging. Our previous study shows that the interaction between …

The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …

Brain microvascular endothelial cells, forming the anatomical site of the blood-brain barrier
(BBB), are widely used as in vitro complements to in vivo BBB studies. Among the …

Plasmodium falciparum-infected erythrocytes (Pf IEs) present P. falciparum erythrocyte
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …

Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium
falciparum parasites; it is characterized by the sequestration of infected red blood cells …

The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …

Ischemic stroke is a primary vascular disease of the central nervous system characterized by
high morbidity, mortality, and healthcare costs. As conventional ischemic stroke models fail …

Plasmodium falciparum, the deadliest form of human malaria, remains one of the major
threats to human health in endemic regions. Its virulence is attributed to its ability to modify …