Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
[HTML][HTML] Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
Background Cerebral microhemorrhages (CMH) are associated with stroke, cognitive
decline, and normal aging. Our previous study shows that the interaction between …
decline, and normal aging. Our previous study shows that the interaction between …
[HTML][HTML] Early passage of Toxoplasma gondii across the blood–brain barrier
EC Ross, GC Olivera, A Barragan - Trends in parasitology, 2022 - cell.com
The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …
[HTML][HTML] Comparative studies between the murine immortalized brain endothelial cell line (bEnd. 3) and induced pluripotent stem cell-derived human brain endothelial …
J Sun, W Ou, D Han, A Paganini-Hill, MJ Fisher… - PLoS …, 2022 - journals.plos.org
Brain microvascular endothelial cells, forming the anatomical site of the blood-brain barrier
(BBB), are widely used as in vitro complements to in vivo BBB studies. Among the …
(BBB), are widely used as in vitro complements to in vivo BBB studies. Among the …
[HTML][HTML] CD36—A host receptor necessary for malaria parasites to establish and maintain infection
A Bachmann, NG Metwally, J Allweier, J Cronshagen… - Microorganisms, 2022 - mdpi.com
Plasmodium falciparum-infected erythrocytes (Pf IEs) present P. falciparum erythrocyte
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …
[HTML][HTML] Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium
falciparum parasites; it is characterized by the sequestration of infected red blood cells …
falciparum parasites; it is characterized by the sequestration of infected red blood cells …
In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy
IO Evbuomwan, OO Alejolowo, TC Elebiyo… - Journal of …, 2024 - Taylor & Francis
The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …
significantly threatens global health. This factor heightens the urgency to explore bioactive …
Engineering Neurovascular Unit and Blood–Brain Barrier for Ischemic Stroke Modeling
Ischemic stroke is a primary vascular disease of the central nervous system characterized by
high morbidity, mortality, and healthcare costs. As conventional ischemic stroke models fail …
high morbidity, mortality, and healthcare costs. As conventional ischemic stroke models fail …
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria
T Zelter, J Strahilevitz, K Simantov, O Yajuk… - EMBO …, 2022 - embopress.org
Plasmodium falciparum, the deadliest form of human malaria, remains one of the major
threats to human health in endemic regions. Its virulence is attributed to its ability to modify …
threats to human health in endemic regions. Its virulence is attributed to its ability to modify …