Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung
cancer and the third leading cause of cancer-related mortality after lung and colon cancer …

Most recent investigations into cancer etiology have identified a key role played by
epigenetics. Specifically, aberrant DNA and histone modifications which silence tumor …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Background The clinical course of prostate cancer (PCa) is highly variable, demanding an
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …

Glutathione S-transferases (GSTs) are phase II drug detoxifying enzymes that play an
essential role in the maintenance of cell integrity and protection against DNA damage by …

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic,
and environmental factors are known to contribute to COPD risk and disease progression …

Purpose Detection of DNA hypermethylation has emerged as a novel molecular biomarker
for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a …

The human genome is diploid, and knowledge of the variants on each chromosome is
important for the interpretation of genomic information. Here we report the assembly of a …

Cancer's complexity is in part due to the presence of intratumor heterogeneity and the
dynamic nature of cancer cell plasticity, which create substantial obstacles in effective …

RASSF1A, one of the eight isoforms of the RASSF1 gene, is a tumor suppressor gene that
influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated …