The successful treatment of many human diseases, including cancer, has come to be
considered a major challenge, as patient response to therapy is difficult to predict. Recently …

Aim: Identification of aberrant hypermethylation in promoter regions of candidate genes to
discover potential biomarkers for colorectal cancer. Materials & Methods: Genes BMP2 …

Epigenetics has been emphasized in the postgenome era to clarify obscure health risks of
environmental toxicants including endocrine disrupting chemicals (EDCs). In addition, mixed …

Background: Prostate-specific antigen (PSA) screening for prostate cancer results in a large
number of unnecessary prostate biopsies. There is a need for specific molecular markers …

We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using
the combined effects of coding and non-coding single nucleotide variants, structural …

Background: Compared to non-recurrent type, recurrent prostate adenocarcinoma (PCa) is
highly fatal, and significantly shortens the survival time of affected patients. Early and …

Breast Cancer, a heterogeneous disease at the molecular level, is the most common cause
of woman mortality worldwide. We used molecular screening and simulation approaches to …

Background: The current study recognizes the significance of estrogen receptor alpha (ERα)
as a member of the nuclear receptor protein family, which holds a central role in the …

Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome
Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation …

Aim We investigated if methylation of candidate genes can be useful for predicting prostate
cancer (PCa) specific death. Patients & methods Methylation of PITX2, WNT5a, SPARC …