[HTML][HTML] Anakinra Pilot–a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants

EA Green, D Metz, R Galinsky, R Atkinson… - Frontiers in …, 2022 - frontiersin.org
Background Bronchopulmonary dysplasia (BPD), its complication pulmonary hypertension
(BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in …

Establishment of a children's Drugs and Therapeutics Committee to ensure evidence‐based and cost‐effective medical treatment for children

SS Holst, CH Møller, C Vermehren… - British Journal of …, 2024 - Wiley Online Library
The prevalence of undocumented medical treatments among children is a significant issue,
as well as many EU countries lack access to newly developed children‐friendly medicines …

[HTML][HTML] Commonly used medications for respiratory and cardiovascular support in neonates: Evidence, knowledge gaps, and future perspectives

E Agakidou, A Kontou, E Chatziioannidis, W Chotas… - Global Pediatrics, 2024 - Elsevier
Critically ill neonates admitted to neonatal intensive care units require specialized
pharmacological treatment due to various medical conditions. However, despite the …

Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data

C Gade, S Trolle, ML Mørk, A Lewis… - Pharmacology …, 2023 - Wiley Online Library
There is currently insufficient knowledge of gestational age dependent medicine disposition
in neonates. Accordingly, the use of off‐label medication, ie, use of medicines outside its …

Novel approaches to postnatal prophylaxis to eliminate vertical transmission of HIV

T Ruel, M Penazzato, JM Zech, M Archary… - … Health: Science and …, 2023 - ghspjournal.org
Novel Approaches to Postnatal Prophylaxis to Eliminate Vertical Transmission of HIV | Global
Health: Science and Practice Skip to main content Main menu Content Current Issue Advance …

[HTML][HTML] Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

L Buyssens, A Valenzuela, S Prims, M Ayuso… - Frontiers in …, 2023 - frontiersin.org
Despite considerable progress in understanding drug metabolism in the human pediatric
population, data remains scarce in preterm neonates. Improving our knowledge of the …

Subgroup identification-based model selection to improve the predictive performance of individualized dosing

H Soeorg, R Kalamees, I Lutsar, T Metsvaht - Journal of Pharmacokinetics …, 2024 - Springer
Currently, model-informed precision dosing uses one population pharmacokinetic model
that best fits the target population. We aimed to develop a subgroup identification-based …

[HTML][HTML] Pharmacokinetics of drugs: newborn perspective

N Bansal, S Momin, R Bansal, SKRG Venkata… - Pediatric …, 2024 - pm.amegroups.org
Safe and effective drug administration are pivotal goals of neonatal pharmacokinetics.
Integrated knowledge of evolving pharmacokinetic principles, physiological characteristics …

[HTML][HTML] Approaches to Reduce the Side Effects of Antibiotic Therapy in Premature Newborns

I Belenichev, O Aliyeva, N Bukhtiyarova… - Medical Sciences …, 2023 - mdpi.com
Significant risk of side effects of drug therapy in newborns, especially in premature
neonates, is associated with immaturity of a number of enzyme systems and …

Novel Approaches to Postnatal Prophylaxis to Eliminate Vertical Transmission of HIV.

M Penazzato, J Zech, M Archary… - … Health: Science and …, 2023 - escholarship.org
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COMMENTARY Novel Approaches to Postnatal Prophylaxis to Eliminate Vertical Transmission …