Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Background Vitamins' deficiency in humans is an important threat worldwide and requires
solutions. In the concept of natural biofactory for bioactive compounds production …

With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …

Many studies indicate a crucial role for the vitamin B12 and folate-dependent enzyme
methionine synthase (MS) in brain development and function, but vitamin B12 status in the …

One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

The societal burden of non-communicable disease is closely linked with environmental
exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the …

Objective To provide updated guidance on pre-conception folic acid and multivitamin
supplementation for primary and secondary (recurrence) prevention of neural tube defects …

Maternal exposure to dietary factors during pregnancy can influence embryonic
development and may modulate the phenotype of offspring through epigenetic …

Does the quality of our diet during early life impact our long-term mental health?
Accumulating evidence suggests that nutrition interacts with our genes and that there is a …

Background Folate and its synthetic form folic acid function as donor of one-carbon units and
have been, together with other B-vitamins, implicated in programming of epigenetic …