Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives

R Zivadinov, M Ramanathan, K Dolic… - Expert review of …, 2011 - Taylor & Francis
Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in multiple
sclerosis patients. CCSVI is characterized by impaired brain venous drainage due to outflow …

[PDF][PDF] Vascular disease in patients with multiple sclerosis: a review

MG Caprio, C Russo, A Giugliano, M Ragucci… - J Vasc Med Surg, 2016 - ibb.cnr.it
Background: despite major advances in immunology and molecular biology, Multiple
Sclerosis is poorly understood with regards to etiology and its immune trigger and causal …

Clinical improvement after extracranial venoplasty in multiple sclerosis

D Hubbard, D Ponec, J Gooding, R Saxon… - Journal of Vascular and …, 2012 - Elsevier
PURPOSE: This study proposed to prospectively evaluate safety and clinical changes in
outpatient endovascular treatment in patients with multiple sclerosis (MS) and chronic …

The negative prognostic role of inflammatory biomarkers in patients with chronic cerebrospinal venous insufficiency

S Song, D Lan, B Jiao, Y Liu, Y Ding, X Ji… - The …, 2023 - journals.lww.com
Background: The pathologic consequences of inflammatory responses in chronic
cerebrospinal venous insufficiency (CCSVI) remains poorly understood. Hence, this study …

Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis

M Blinkenberg, P Åkeson, H Sillesen… - Acta neurologica …, 2012 - Wiley Online Library
Objectives The traditional view that multiple sclerosis (MS) is an autoimmune disease has
recently been challenged by the claim that MS is caused by chronic cerebrospinal venous …

Small internal jugular veins with restricted outflow are associated with severe multiple sclerosis: a sonographer-blinded, case–control ultrasound study

Ž Krsmanović, M Živković, T Lepić, A Stanković… - BMC neurology, 2013 - Springer
Background Recent evidence has indicated an association between chronic cerebrospinal
venous insufficiency (CCSVI) and multiple sclerosis. Small internal jugular veins (IJVs)(with …

Non-specific alterations of craniocervical venous drainage in multiple sclerosis revealed by cardiac-gated phase-contrast MRI

B Ertl-Wagner, I Koerte, T Kümpfel… - Multiple Sclerosis …, 2012 - journals.sagepub.com
Objective: There is an on-going controversy about venous drainage abnormalities in
multiple sclerosis (MS). We applied cardiac-gated phase-contrast and venographic …

Chronic cerebrospinal venous insufficiency: pitfalls and perils of sonographic assessment

ESH Kim, C Diaconu, L Baus, RJ Fox… - … of Ultrasound in …, 2015 - Wiley Online Library
Objectives Duplex sonography has been proposed as a diagnostic modality for detection of
chronic cerebrovascular venous insufficiency, a recently proposed hypothesis of multiple …

[PDF][PDF] Role of Chlamydophila pneumoniae in the Pathogenesis of Chronic Cerebrospinal Venous Insuffiency in Patients with Multiple Sclerosis

C Contini, E Granieri, E Fainardi… - J Mult Scler (Foster …, 2015 - researchgate.net
Although the aetiology of Multiple Sclerosis (MS) is unknown, genetic and environmental
factors including infectious agents may play a role in the development of this disease …

Epidemiology of multiple sclerosis has had its day: there are no more unanswered questions-Commentary

M Hutchinson - Multiple Sclerosis Journal, 2012 - journals.sagepub.com
A provocative statement but chosen for a reason. The nature of debate is around the
definition or concept of epidemiology. August Hirsch in the 19 th century described it as the …