Recently, advances in molecular biology and bioinformatics have allowed a more thorough
understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) …

Pituitary neuroendocrine tumors (PitNETs) are the most common pituitary tumors and the
second most common brain tumors. Although the vast majority (> 90%) are benign, a small …

The long-standing view of senescent cells as passive and dysfunctional biological remnants
has recently shifted into a new paradigm where they are main players in the development of …

Simple Summary Mutational hotspots have gained importance as oncological biomarkers in
recent years because of their potential as predictors of clinical outcomes and/or therapeutic …

Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory
behavior are the rare subset that progress after surgery, conventional medical therapies …

Plurihormonal pituitary adenoma (PPA) is a type of pituitary tumor capable of producing two
or more hormones and usually presents as an aggressive, large adenoma. As yet, its …

Graphical abstract Abstract The 5th edition of the World Health Organization (WHO)
classification of neuroendocrine neoplasms (NENs) is built to achieve a uniform terminology …

Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial
neoplasms. Although they usually appear to be benign, some tumors display worse …

Background The 2022 World Health Organization (WHO) classification of pituitary
neuroendocrine tumour (PitNET) supersedes the previous one in 2017 and further …

Purpose For asymptomatic non-functioning pituitary adenomas (NFPAs), conservative
approaches such as observation are preferred. However, some NFPAs exhibit poor …