Inappropriate activation of the renin-angiotensin system (RAS) exacerbates renal and
vascular injury. Accordingly, treatment with global RAS antagonists attenuates …

Sodium intake is undoubtedly indispensable for normal body functions but can be
detrimental when taken in excess of dietary requirements. The consequences of excessive …

Low-grade inflammatory processes and related oxidative stress may have a key role in the
pathogenesis of hypertension and hypertension-mediated organ damage. Innate immune …

Immune mechanisms have been recognized to have a role in the pathogenesis of
hypertension, vascular disease and kidney damage in humans and animals for many …

Oxidative stress is a major hallmark of cardiovascular diseases although a causal link was
so far not proven by large clinical trials. However, there is a close association between …

Understanding the causal role of the immune and inflammatory responses in hypertension
has led to questions regarding the links between hypertension and autoimmunity. Immune …

Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …

The causative role of inflammation in hypertension-related cardiovascular diseases is
evident and calls for development of specific immunomodulatory therapies. We tested the …

The association between periodontal disease and systemic disease has become a research
hotspot. Porphyromonas gingivalis (P. gingivalis), a crucial periodontal pathogen, affects the …

Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …