Pharmacogenomics in the treatment of inflammatory bowel disease
MA Smith, AM Marinaki, JD Sanderson - Pharmacogenomics, 2010 - Taylor & Francis
In recent years, the benefits of early aggressive treatment paradigms for inflammatory bowel
disease have emerged. Symptomatic improvement is no longer considered adequate; …
disease have emerged. Symptomatic improvement is no longer considered adequate; …
Patients' induced pluripotent stem cells to model drug induced adverse events: a role in predicting thiopurine induced pancreatitis?
Induced pluripotent stem cells (iPSC) can be produced from adult cells by transfecting them
with a definite set of pluripotency-associated genes. Under adequate growth conditions and …
with a definite set of pluripotency-associated genes. Under adequate growth conditions and …
Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT*3 alleles
Aim: SNPs in the gene for TPMT exemplify one of the most successful translations of
pharmacogenomics into clinical practice. This study explains the correlation between …
pharmacogenomics into clinical practice. This study explains the correlation between …
基因多态性对巯嘌呤类药物作用影响的研究进展
谢偲， 岳丽杰 - 中国临床药理学与治疗学, 2014 - manu41.magtech.com.cn
基因多态性是影响巯嘌呤类药物在体内代谢, 最终造成药物疗效和毒性差异的主要原因.
近年来研究发现, 单一药物代谢酶或转运体的基因多态性与巯嘌呤类药物临床不良反应不完全 …
近年来研究发现, 单一药物代谢酶或转运体的基因多态性与巯嘌呤类药物临床不良反应不完全 …
The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine
MMTJ Broekman, DR Wong, GJA Wanten… - The …, 2018 - nature.com
The conversion of azathioprine (AZA) to mercaptopurine (MP) is mediated by glutathione
transferase Mu1 (GSTM1), alpha1 (GSTA1) and alpha2 (GSTA2). We designed a case …
transferase Mu1 (GSTM1), alpha1 (GSTA1) and alpha2 (GSTA2). We designed a case …
Genetic variants of glutathione S-transferases μ, θ, and π display no susceptibility to inflammatory bowel disease in the Danish population
A Ernst, V Andersen, M Østergaard… - Scandinavian journal …, 2010 - Taylor & Francis
Introduction. A combination of genetic predisposition and interactions with environmental
factors are believed to be responsible for disease phenotype and disease progression in …
factors are believed to be responsible for disease phenotype and disease progression in …
Combining explainable machine learning, demographic and multi-omic data to identify precision medicine strategies for inflammatory bowel disease
LJ Gardiner, AP Carrieri, K Bingham, G Macluskie… - medRxiv, 2021 - medrxiv.org
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect
several million individuals worldwide. These diseases are heterogeneous at the clinical …
several million individuals worldwide. These diseases are heterogeneous at the clinical …
A novel ABCC6 haplotype is associated with azathioprine drug response in myasthenia gravis
L Colleoni, B Galbardi, C Barzago… - Pharmacogenetics …, 2017 - journals.lww.com
Objective We investigated the association of single nucleotide polymorphisms (SNPs) in
drug-metabolizing enzymes and transporters (DMETs) with the response to azathioprine …
drug-metabolizing enzymes and transporters (DMETs) with the response to azathioprine …