[HTML][HTML] Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

[HTML][HTML] NK cells and solid tumors: therapeutic potential and persisting obstacles

L Tong, C Jiménez-Cortegana… - Molecular …, 2022 - molecular-cancer.biomedcentral …
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma

MC Burger, MT Forster, A Romanski… - Neuro …, 2023 - academic.oup.com
Background Glioblastoma (GB) is incurable at present without established treatment options
for recurrent disease. In this phase I first-in-human clinical trial we investigated safety and …

[HTML][HTML] Current landscape and future directions of bispecific antibodies in cancer immunotherapy

J Wei, Y Yang, G Wang, M Liu - Frontiers in Immunology, 2022 - frontiersin.org
Recent advances in cancer immunotherapy using monoclonal antibodies have dramatically
revolutionized the therapeutic strategy against advanced malignancies, inspiring the …

[HTML][HTML] The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

S Curio, GT Belz - Cellular & Molecular Immunology, 2022 - nature.com
Cancer is a complex disease, and despite incredible progress over the last decade, it
remains the leading cause of death worldwide. Liver cancers, including hepatocellular …

[HTML][HTML] Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

H Tian, J Cao, B Li, EC Nice, H Mao, Y Zhang… - Bone Research, 2023 - nature.com
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

[HTML][HTML] Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies

B Seliger, U Koehl - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells belong to the family of innate immune cells with the capacity to
recognize and kill tumor cells. Different phenotypes and functional properties of NK cells …

[HTML][HTML] Nanomaterials: A powerful tool for tumor immunotherapy

Z Chen, Z Yue, R Wang, K Yang, S Li - Frontiers in Immunology, 2022 - frontiersin.org
Cancer represents the leading global driver of death and is recognized as a critical obstacle
to increasing life expectancy. In recent years, with the development of precision medicine …

The Ion Channel Gene KCNAB2 Is Associated with Poor Prognosis and Loss of Immune Infiltration in Lung Adenocarcinoma

Y Lyu, Q Wang, J Liang, L Zhang, H Zhang - Cells, 2022 - mdpi.com
The malignancy with the greatest global mortality rate is lung cancer. Lung adenocarcinoma
(LUAD) is the most common subtype. The evidence demonstrated that voltage-gated …

[HTML][HTML] Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

E Shin, SH Bak, T Park, JW Kim, SR Yoon… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …