High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

The flowering plant Arabidopsis thaliana is a dicot model organism for research in many
aspects of plant biology. A comprehensive annotation of its genome paves the way for …

The human transcriptome is composed of a vast RNA population that undergoes further
diversification by splicing. Detecting specific splice sites in this large sequence pool is the …

Single-cell genome, DNA methylome, and transcriptome sequencing methods have been
separately developed. However, to accurately analyze the mechanism by which …

A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

Abstract The Encyclopedia of DNA Elements (ENCODE) Project is in its third phase of
creating a comprehensive catalog of functional elements in the human genome. This phase …

Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …

The reference human genome sequence is inarguably the most important and widely used
resource in the fields of human genetics and genomics. It has transformed the conduct of …