Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …

In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the
gastrointestinal tract. Although the precise etiology of IBD remains incompletely understood …

Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic
syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of …

Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Hepatic lipid overloading mainly in the form of triglycerides is considered a prerequisite for
the development of nonalcoholic fatty liver disease (NAFLD). However, triglyceride …

Metabolomics, one of the 'omic'sciences in systems biology, is the global assessment and
validation of endogenous small-molecule metabolites within a biologic system. Analysis of …

Metabolomics is a promising “omics” field in systems biology; its objective is comprehensive
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …

ABSTRACT Stearoyl CoA desaturase 1 (SCD1) catalyzes the rate-limiting step in the
production of MUFA that are major components of tissue lipids. Alteration in SCD1 …