Multifarious roles of sialic acids in immunity

A Varki, P Gagneux - Annals of the New York Academy of …, 2012 - Wiley Online Library
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

MM Vicente, E Leite-Gomes, SS Pinho - Trends in Immunology, 2023 - cell.com
Glycans cover the surfaces of all mammalian cells through a process called glycosylation.
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …

Polysialic acid: Biosynthesis, novel functions and applications

KJ Colley, K Kitajima, C Sato - Critical reviews in biochemistry and …, 2014 - Taylor & Francis
As an anti-adhesive, a reservoir for key biological molecules, and a modulator of signaling,
polysialic acid (polySia) is critical for nervous system development and maintenance …

Disialic, oligosialic and polysialic acids: distribution, functions and related disease

C Sato, K Kitajima - The journal of biochemistry, 2013 - academic.oup.com
Sialic acids (Sia) are involved in many biological activities and frequently exist as monosialyl
residues at the non-reducing terminal end of glycoconjugates. Occasionally, polymerized …

Added prognostic value of secondary AML-like gene mutations in ELN intermediate-risk older AML: ALFA-1200 study results

C Gardin, C Pautas, E Fournier, R Itzykson… - Blood …, 2020 - ashpublications.org
In this study, we aimed to refine prognostication of older with acute myeloid leukemia (AML)
after intensive chemotherapy. Five hundred and nine patients aged 60 years or older …

Glycans as shapers of tumour microenvironment: a sweet driver of T‐cell‐mediated anti‐tumour immune response

A Fernandes, CM Azevedo, MC Silva, G Faria… - …, 2023 - Wiley Online Library
Essentially all cells are covered with a dense coat of different glycan structures/sugar chains,
giving rise to the so‐called glycocalyx. Changes in cellular glycosylation are a hallmark of …

Hematopoietic progenitor migration to the adult thymus

DA Zlotoff, A Bhandoola - Annals of the New York Academy of …, 2011 - Wiley Online Library
Although most hematopoietic lineages develop in the bone marrow (BM), T cells uniquely
complete their development in the specialized environment of the thymus. Hematopoietic …

Polysialic acid in the immune system

TM Villanueva-Cabello… - Frontiers in …, 2022 - frontiersin.org
Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …

Role of neuropilin-2 in the immune system

S Schellenburg, A Schulz, DM Poitz, MH Muders - Molecular Immunology, 2017 - Elsevier
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are
dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are …

Multiple roles of glycans in hematological malignancies

X Pang, H Li, F Guan, X Li - Frontiers in oncology, 2018 - frontiersin.org
The three types of blood cells (red blood cells for carrying oxygen, white blood cells for
immune protection, and platelets for wound clotting) arise from hematopoietic …