Plant-derived compounds have recently attracted greater interest in the field of new
therapeutic agent development. These compounds have been widely screened for their …

Various antidepressants are commonly used to treat depression and anxiety disorders, and
sex differences have been identified in their efficacy and side effects. Steroids, such as …

The use of animal models for behavioral and pharmaceutical testing is employed in many
different fields of research but often relies solely on male animals. When females are …

Chrysin (5, 7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora
coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts …

Aging in women is associated with low estrogen, but also with cognitive decline and
affective disorders. Whether low estrogen is causally responsible for these behavioral …

Low concentrations of ovarian hormones, among other factors, are associated with greater
vulnerability to negative effects of environmental stressors and may trigger anxiety …

Estrogen replacement therapy (ERT) has been proven to relieve menopausal-related mental
disorders including depression in postmenopausal women. However, the unsafety of ERT …

Menopause is a clinical term that indicates the end of the reproductive period of women that
occurs naturally; however, it can be induced by bilateral oophorectomy, which is commonly …

Background Menopause predisposes individuals to affective disorders, such as depression,
which is tightly related to neuroinflammation. While the neuroinflammatory condition has …

About 350 million people worldwide suffered from depression, but less than half of the
patients received effective and regular treatments. Traditional Chinese Medicine (TCM) such …