Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting 1–2% of the general
population. A number of studies have demonstrated that AF, and in particular lone AF, has a …

Atrial fibrillation (AF) is the most common cardiac rhythm disorder and the prevalence is
increasing. The disease confers an increased risk of severe complications such as heart …

Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased
morbidity. As the population ages and the prevalence of AF continues to rise, the …

Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

Simple Summary Atrial fibrillation (AF) represents a worldwide medical problem contributing
to substantial morbidity, mortality and social-economic burden. Gap junctions and their …

The heart is a complex organ composed of multiple cell types, including cardiomyocytes and
different non-myocyte populations, all working closely together to determine the hearts …

Internalization of gap junction plaques results in the formation of annular gap junction
vesicles. The factors that regulate the coordinated internalization of the gap junction plaques …

Atrial fibrillation (AF) is the most-common sustained arrhythmia observed in clinical practice,
but response to therapy is highly variable between patients. Current drug therapies to …