Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Activatable fluorescent probes for real-time imaging-guided tumor therapy

QJ Duan, ZY Zhao, YJ Zhang, L Fu, YY Yuan… - Advanced Drug Delivery …, 2023 - Elsevier
Surgery and drug therapy are the two principal options for cancer treatment. However, their
clinical benefits are hindered by the difficulty of accurate location of the tumors and timely …

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

S Hernot, L van Manen, P Debie, JSD Mieog… - The lancet …, 2019 - thelancet.com
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Graphene quantum dots (GQDs) for bioimaging and drug delivery applications: a review

MC Biswas, MT Islam, PK Nandy… - ACS Materials …, 2021 - ACS Publications
Quantum dots (QDs) exhibit unique physicochemical and optical properties that are suitable
for photovoltaic cells, light-emitting diodes, and optoelectronic devices; however, unlike …

Organic semiconducting agents for deep‐tissue molecular imaging: second near‐infrared fluorescence, self‐luminescence, and photoacoustics

Q Miao, K Pu - Advanced materials, 2018 - Wiley Online Library
Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of
relatively low tissue penetration and poor signal‐to‐background ratio due to light scattering …

A small-molecule dye for NIR-II imaging

AL Antaris, H Chen, K Cheng, Y Sun, G Hong, C Qu… - Nature materials, 2016 - nature.com
Fluorescent imaging of biological systems in the second near-infrared window (NIR-II) can
probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of …

Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: a randomized …

QY Chen, JW Xie, Q Zhong, JB Wang, JX Lin, J Lu… - JAMA …, 2020 - jamanetwork.com
Importance The application of indocyanine green (ICG) imaging in laparoscopic radical
gastrectomy is in the preliminary stages of clinical practice, and its safety and efficacy remain …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Fluorescence-guided surgery

T Nagaya, YA Nakamura, PL Choyke… - Frontiers in …, 2017 - frontiersin.org
Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

AV DSouza, H Lin, ER Henderson… - … of biomedical optics, 2016 - spiedigitallibrary.org
There is growing interest in using fluorescence imaging instruments to guide surgery, and
the leading options for open-field imaging are reviewed here. While the clinical fluorescence …