Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

In humans, tissue injury and depression can both cause pain hypersensitivity, but whether
this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic …

There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …

Methadone is increasingly being used for its analgesic properties. Despite the increasing
popularity, many healthcare providers are not familiar with methadone's complex …

Objective The development of effective anti-obesity therapeutics relies heavily on the ability
to target specific brain homeostatic and hedonic mechanisms controlling body weight. To …

Recent findings linked gastrointestinal disorders characterized by abdominal pain to gut
microbiota composition. The present work aimed to evaluate the power of gut microbiota as …

Chronic neuropathic pain (CNP) refers to pain that lasts for more than three months due to a
disease or an injury to the somatosensory nervous system. The incidence of CNP has been …

Descending control of nociception (DCN; also known as conditioned pain modulation [CPM],
the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby …

INTRODUCTION—Chronic pain is one of the most common reasons that patients seek
medical attention. Chronic pain results from combined biologic, psychologic, and social …