The use of cold preservation solutions to rapidly flush and cool the kidney followed by static
cold storage in ice has been the standard kidney preservation technique for the last 50 y …

Ischemia reperfusion injury is a complex process consisting of a seemingly chaotic but
actually organized and compartmentalized shutdown of cell function, of which oxidative …

Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce
ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney …

The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …

Great efforts have been made toward addressing the demand for donor kidneys. One of the
most promising approaches is to use kidneys from donation after circulatory death donors …

Pigs represent a potentially attractive model for medical research. Similar body size and
physiological patterns of kidney injury that more closely mimic those described in humans …

Background The glucose derivative 3-O-methyl-D-glucose (OMG) is used as a
cryoprotectant in freezing cells. However, its protective role and the related mechanism in …

Early insults associated with cardiac transplantation increase the immunogenicity of donor
microvascular endothelial cells (ECs), which interact with recipient alloreactive memory T …

Introduction: Delayed graft function (DGF) has a significant impact on kidney transplantation
outcome. One of the underlying pivotal mechanisms is organ preservation and associated …

The use of high-risk renal grafts for transplantation requires the optimization of pretransplant
assessment and preservation reconditioning strategies to decrease the organ discard rate …