The pig: a model for human infectious diseases

F Meurens, A Summerfield, H Nauwynck, L Saif… - Trends in …, 2012 - cell.com
An animal model to study human infectious diseases should accurately reproduce the
various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to …

How bacteria could cause cancer: one step at a time

AJ Lax, W Thomas - Trends in microbiology, 2002 - cell.com
Helicobacter pylori highlighted the potential for bacteria to cause cancer. It is becoming clear
that chronic infection with other bacteria, notably Salmonella typhi, can also facilitate tumour …

Differences in Genotypes of Helicobacter pylori from Different Human Populations

D Kersulyte, AK Mukhopadhyay… - Journal of …, 2000 - Am Soc Microbiol
ABSTRACT DNA motifs at several informative loci in more than 500 strains of Helicobacter
pylori from five continents were studied by PCR and sequencing to gain insights into the …

Human microbiota-associated swine: current progress and future opportunities

M Wang, SM Donovan - ILAR journal, 2015 - academic.oup.com
Gnotobiotic (GN) rodent models have provided insight into the contributions of the gut
microbiota to host health and preventing disease. However, rodent models are limited by …

The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts

W Gonciarz, A Krupa, K Hinc, M Obuchowski… - PLoS …, 2019 - journals.plos.org
Background Helicobacter pylori colonizes the human gastric mucosa, causing chronic
inflammation, peptic ulcers and gastric cancer. A cascade of harmful processes results from …

Board invited review: The pig microbiota and the potential for harnessing the power of the microbiome to improve growth and health

ND Aluthge, DM Van Sambeek… - Journal of animal …, 2019 - academic.oup.com
A variety of microorganisms inhabit the gastrointestinal tract of animals including bacteria,
archaea, fungi, protozoa, and viruses. Pioneers in gut microbiology have stressed the critical …

Specific Entry of Helicobacter pylori into Cultured Gastric Epithelial Cells via a Zipper-Like Mechanism

T Kwok, S Backert, H Schwarz, J Berger… - Infection and …, 2002 - Am Soc Microbiol
Although Helicobacter pylori has generally been considered an extracellular pathogen, a
number of in vitro infection experiments and biopsy examinations have shown that it is …

Animal models of Campylobacter jejuni colonization and disease and the lessons to be learned from similar Helicobacter pylori models

DG Newell - Journal of Applied Microbiology, 2001 - academic.oup.com
The mechanisms by which Campylobacter jejuni induces disease in human beings remain
unknown. Identification of campylobacter virulence factors requires appropriate animal …

Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of …

W Gonciarz, M Walencka, AP Moran, K Hinc… - Journal of biomedical …, 2019 - Springer
Background Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic
inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori …

Vaccine development for Nipah virus infection in pigs

RK McLean, SP Graham - frontiers in Veterinary Science, 2019 - frontiersin.org
Nipah virus (NiV) causes a severe and often fatal neurological disease in humans. Whilst
fruit bats are considered the natural reservoir, NiV also infects pigs and may cause an …