Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
X Jiang, J Wang, X Deng, F Xiong, J Ge, B Xiang, X Wu… - Molecular cancer, 2019 - Springer
Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …
mechanisms of tumor immune escape, including immunosuppression, which has become a …
[PDF][PDF] One year in review 2018: pathogenesis of rheumatoid arthritis
E Calabresi, F Petrelli, AF Bonifacio… - Clin Exp …, 2018 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects joints. The several mechanisms involved in the development of the disease are not …
affects joints. The several mechanisms involved in the development of the disease are not …
A phase 2 trial of peresolimab for adults with rheumatoid arthritis
J Tuttle, E Drescher, JA Simón-Campos… - … England Journal of …, 2023 - Mass Medical Soc
Background Peresolimab is a humanized IgG1 monoclonal antibody designed to stimulate
the endogenous programmed cell death protein 1 (PD-1) inhibitory pathway. Stimulation of …
the endogenous programmed cell death protein 1 (PD-1) inhibitory pathway. Stimulation of …
Soluble programmed death ligand-1 (sPD-L1): a pool of circulating proteins implicated in health and diseases
Simple Summary The interaction of programmed cell death ligand-1 (PDL1) with its receptor
PD1 inhibits T-cell responses. Blockade of this interaction with monoclonal antibodies leads …
PD1 inhibits T-cell responses. Blockade of this interaction with monoclonal antibodies leads …
Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation
M Wu, Q Huang, Y Xie, X Wu, H Ma, Y Zhang… - Journal of hematology & …, 2022 - Springer
Immune checkpoint molecules are promising anticancer targets, among which therapeutic
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …
What are the dominant cytokines in early rheumatoid arthritis?
LA Ridgley, AE Anderson, AG Pratt - Current opinion in …, 2018 - journals.lww.com
Successful therapeutic stratification will depend upon an increasingly sophisticated
appreciation of how dominant players amongst cytokine networks vary across time and …
appreciation of how dominant players amongst cytokine networks vary across time and …
YY1 regulates cancer cell immune resistance by modulating PD-L1 expression
E Hays, B Bonavida - Drug Resistance Updates, 2019 - Elsevier
Recent advances in the treatment of various cancers have resulted in the adaptation of
several novel immunotherapeutic strategies. Notably, the recent intervention through …
several novel immunotherapeutic strategies. Notably, the recent intervention through …
The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients …
B Chang, T Huang, H Wei, L Shen, D Zhu, W He… - Cancer Immunology …, 2019 - Springer
Background Blocking the programmed death protein 1 (PD-1)/programmed death-ligand 1
(PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in …
(PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in …
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression
Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated
antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and …
antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and …
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
A Petrelli, G Mijnheer… - The Journal of …, 2018 - Am Soc Clin Investig
Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the
tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T …
tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T …