Manganese (Mn) is an essential element that is involved in the synthesis and activation of
many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In …

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐
body energy status and metabolism; it not only stores excess energy but also secretes …

Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …

Differentiated 3T3-L1 adipocytes are a widely used in vitro model of white adipocytes. In
addition to classical white and brown adipocytes that are derived from different cell lineages …

Drugs that recapitulate aspects of the exercise adaptive response have the potential to
provide better treatment for diseases associated with physical inactivity. We previously …

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox
signaling and programmed cell death. Deficiency in AIF is known to result in defective …

Genome-wide association studies (GWAS), relying on hundreds of thousands of individuals,
have revealed> 200 genomic loci linked to metabolic disease (MD). Loss of insulin …