Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects

F Marangoni, C Agostoni, C Borghi, AL Catapano… - Atherosclerosis, 2020 - Elsevier
This narrative review aims to discuss the more relevant evidence on the role of linoleic acid
(LA), a n-6 essential fatty acid that constitutes the predominant proportion of dietary …

The eicosapentaenoic acid: arachidonic acid ratio and its clinical utility in cardiovascular disease

JR Nelson, S Raskin - Postgraduate medicine, 2019 - Taylor & Francis
Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain
polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid …

[HTML][HTML] Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

FJ Osuna-Prieto, B Martinez-Tellez… - Cardiovascular …, 2021 - Springer
Background Succinate is produced by both host and microbiota, with a key role in the
interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory …

[HTML][HTML] Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies

J Li, M Guasch-Ferré, Y Li, FB Hu - The American journal of clinical nutrition, 2020 - Elsevier
Background Current evidence on associations between intakes of linoleic acid (LA), the
predominant n–6 (ω-6) fatty acid, and mortality is inconsistent and has not been summarized …

The Omega-6: Omega-3 ratio: A critical appraisal and possible successor

WS Harris - Prostaglandins, Leukotrienes and Essential Fatty Acids, 2018 - Elsevier
The well-known health effects of the long-chain, marine omega-3 (n-3) fatty acids (FAs) has
led to a growing interest in the prognostic value that blood levels of these FAs might have vis …

Role of omega‐6 and omega‐3 fatty acids in fetal programming

N Shrestha, SL Sleep, JSM Cuffe… - Clinical and …, 2020 - Wiley Online Library
Maternal nutrition plays a critical role in fetal development and can influence adult onset of
disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are major omega‐6 (n‐6) and n …

Microbial metabolites in chronic heart failure and its common comorbidities

S Hua, B Lv, Z Qiu, Z Li, Z Wang, Y Chen… - EMBO Molecular …, 2023 - embopress.org
This study aimed to identify microbial signatures that contribute to the shared etiologies
between chronic heart failure (CHF), type 2 diabetes, and chronic kidney disease. The …

[HTML][HTML] Association of dietary n3 and n6 fatty acids intake with hypertension: NHANES 2007–2014

J Chen, B Sun, D Zhang - Nutrients, 2019 - mdpi.com
We conducted this cross-sectional study in the American general population to explore the
association of dietary n3 and n6 fatty acids intake and the risk of hypertension. We used data …

Dietary intake, biomarkers and supplementation of fatty acids and risk of coronary events: a systematic review and dose-response meta-analysis of randomized …

A Jayedi, S Soltani, A Emadi, K Ghods… - Critical Reviews in …, 2023 - Taylor & Francis
We aimed to review the association of dietary fats and risk of coronary events in adults. We
searched PubMed, Embase, CENTRAL, Scopus, and Web of Sciences to April 2022 for …

[HTML][HTML] Omega-3 fatty acids in heart disease—why accurately measured levels matter

C Von Schacky, RS Kuipers, H Pijl, FAJ Muskiet… - Netherlands Heart …, 2023 - Springer
Current guidelines barely support marine omega‑3 fatty acids eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA) in cardiology, mainly because results of large trials were …