The approach to molecular genetic studies of complex phenotypes evolved considerably
during the recent years. The candidate gene approach, which is restricted to an analysis of a …

DNA sequence variants are major components of the “causal field” for virtually all medical
phenotypes, whether single gene familial disorders or complex traits without a clear familial …

The new findings suggest a multifarious nature of the 'missing heritability'. The findings de-
emphasize the focus on delineating the basis of 'missing heritability'and shift the focus to …

Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …

In this review, we discuss the genetic architecture of obesity and the metabolic syndrome,
highlighting recent advances in identifying genetic variants and loci responsible for a portion …

The cell plasma membrane serves as a nexus integrating extra-and intracellular
components, which together enable many of the fundamental cellular signaling processes …

Hepatitis E viral (HEV) infection imposes a heavy health burden worldwide and is common
in the United States. Previous investigations of risks addressed environmental and host …

Coronary atherosclerosis is a complex heritable trait with an enigmatic genetic etiology.
Genome-wide association studies (GWAS) have successfully led to identification of over 100 …

This study investigated interactions between dietary fat intake and IL-6 polymorphisms on
obesity and serum lipids in black and white South African (SA) women. Normal-weight and …

Premature ovarian insufficiency (POI), defined as loss of normal ovarian functions before the
age of 40 years, occurs in at least 1% of all women. It affects the reproductive system and …