Opioid analgesia and opioid-induced adverse effects: a review
AK Paul, CM Smith, M Rahmatullah, V Nissapatorn… - Pharmaceuticals, 2021 - mdpi.com
Opioids are widely used as therapeutic agents against moderate to severe acute and
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …
Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders
MA Lebow, A Chen - Molecular psychiatry, 2016 - nature.com
The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …
Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches
Abstract The United States is in the midst of an opioid addiction and overdose crisis
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
Endogenous opioid peptides in the descending pain modulatory circuit
EE Bagley, SL Ingram - Neuropharmacology, 2020 - Elsevier
The opioid epidemic has led to a serious examination of the use of opioids for the treatment
of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the …
of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the …
Electrochemical analysis of neurotransmitters
ES Bucher, RM Wightman - Annual review of analytical …, 2015 - annualreviews.org
Chemical signaling through the release of neurotransmitters into the extracellular space is
the primary means of communication between neurons. More than four decades ago, Ralph …
the primary means of communication between neurons. More than four decades ago, Ralph …
Dynorphin controls the gain of an amygdalar anxiety circuit
NA Crowley, DW Bloodgood, JA Hardaway, AM Kendra… - Cell reports, 2016 - cell.com
Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states,
including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been …
including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been …
Food addiction and binge eating: lessons learned from animal models
MG Novelle, C Diéguez - Nutrients, 2018 - mdpi.com
The feeding process is required for basic life, influenced by environment cues and tightly
regulated according to demands of the internal milieu by regulatory brain circuits. Although …
regulated according to demands of the internal milieu by regulatory brain circuits. Although …
Neurobiology of alcohol seeking behavior
Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …
stop or control alcohol use despite adverse consequences. A main challenge of addiction …
Food-derived opioid peptides in human health: A review
World Health Organization data suggest that stress, depression, and anxiety have a
noticeable prevalence and are becoming some of the most common causes of disability in …
noticeable prevalence and are becoming some of the most common causes of disability in …
Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans
AK Bershad, JH Jaffe, E Childs, H de Wit - Psychoneuroendocrinology, 2015 - Elsevier
Pre-clinical and clinical evidence indicates that opioid drugs have stress-dampening effects.
In animal models, opioid analgesics attenuate responses to isolation distress, and in …
In animal models, opioid analgesics attenuate responses to isolation distress, and in …