MITF in melanoma: mechanisms behind its expression and activity

ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

“Transcription physiology” of pigment formation in melanocytes: central role of MITF

J Vachtenheim, J Borovanský - Experimental dermatology, 2010 - Wiley Online Library
Please cite this paper as:“Transcription physiology” of pigment formation in melanocytes:
central role of (MITF). Experimental Dermatology 2010; 19: 617–627. Abstract: Melanin …

Characterization of a melanocyte progenitor population in human interfollicular epidermis

K Michalak-Mićka, VL Büchler, N Zapiórkowska-Blumer… - Cell reports, 2022 - cell.com
It is still unknown whether the human interfollicular epidermis harbors a reservoir of
melanocyte precursor cells. Here, we clearly distinguish between three distinct types of …

Biallelic mutations in MITF cause coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness

A George, DJ Zand, RB Hufnagel, R Sharma… - The American Journal of …, 2016 - cell.com
Human MITF is, by convention, called the" microphthalmia-associated transcription factor"
because of previously published seminal mouse genetic studies; however, mutations in …

Modulating transcription factor activity: Interfering with protein-protein interaction networks

M Francois, P Donovan, F Fontaine - Seminars in cell & developmental …, 2020 - Elsevier
Biophysical parameters that govern transcription factors activity are binding locations across
the genome, dwelling time at these regulatory elements and specific protein-protein …

MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function

C Grill, K Bergsteinsdóttir… - Human Molecular …, 2013 - academic.oup.com
The basic-helix–loop–helix-leucine zipper (bHLHZip) protein MITF (microphthalmia-
associated transcription factor) is a master regulator of melanocyte development. Mutations …

Caffeic acid phenethyl ester inhibits alpha-melanocyte stimulating hormone-induced melanin synthesis through suppressing transactivation activity of microphthalmia …

JY Lee, HJ Choi, TW Chung, CH Kim… - Journal of Natural …, 2013 - ACS Publications
Caffeic acid phenethyl ester (1), a natural compound found in various plants and propolis, is
a well-known anti-inflammatory, immunomodulatory, and cytotoxic agent. The present study …

Microphthalmia‐associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

J Vachtenheim, L Ondrušová - Experimental dermatology, 2015 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) is a nodal point in melanoma
transcriptional network that regulates dozens of genes with critical functions in cell …

SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells

J Vachtenheim, L Ondrušová, J Borovanský - Biochemical and biophysical …, 2010 - Elsevier
The microphthalmia-associated transcription factor (MITF) is required for melanocyte
development, maintenance of the melanocyte-specific transcription, and survival of …

The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300

AD Brown, K Lynch, DN Langelaan - Scientific Reports, 2023 - nature.com
The microphthalmia-associated transcription factor (MITF) is one of four closely related
members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular …