Beyond mass spectrometry, the next step in proteomics
Proteins can be the root cause of a disease, and they can be used to cure it. The need to
identify these critical actors was recognized early (1951) by Sanger; the first biopolymer …
identify these critical actors was recognized early (1951) by Sanger; the first biopolymer …
Overview of the materials design and sensing strategies of nanopore devices
L Liang, F Qin, S Wang, J Wu, R Li, Z Wang… - Coordination Chemistry …, 2023 - Elsevier
Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …
leads the development of various domains. Herein we first briefly introduce the …
[HTML][HTML] Protein identification by nanopore peptide profiling
Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their
applicability towards full protein identification has yet to be demonstrated. Here, we show …
applicability towards full protein identification has yet to be demonstrated. Here, we show …
[HTML][HTML] FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution
A high throughput single-molecule method for identifying peptides and sequencing proteins
based on nanopores could reduce costs and increase speeds of sequencing, allow the …
based on nanopores could reduce costs and increase speeds of sequencing, allow the …
[HTML][HTML] Digital immunoassay for biomarker concentration quantification using solid-state nanopores
Single-molecule counting is the most accurate and precise method for determining the
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …
Machine Learning Assisted Simultaneous Structural Profiling of Differently Charged Proteins in a Mycobacterium smegmatis Porin A (MspA) Electroosmotic Trap
The nanopore is emerging as a means of single-molecule protein sensing. However,
proteins demonstrate different charge properties, which complicates the design of a sensor …
proteins demonstrate different charge properties, which complicates the design of a sensor …
Protein Sizing with 15 nm Conical Biological Nanopore YaxAB
S Straathof, G Di Muccio, M Yelleswarapu… - ACS …, 2023 - ACS Publications
Nanopores are promising single-molecule tools for the electrical identification and
sequencing of biomolecules. However, the characterization of proteins, especially in real …
sequencing of biomolecules. However, the characterization of proteins, especially in real …
Electro-osmotic vortices promote the capture of folded proteins by PlyAB nanopores
G Huang, K Willems, M Bartelds, P Van Dorpe… - Nano …, 2020 - ACS Publications
Biological nanopores are emerging as powerful tools for single-molecule analysis and
sequencing. Here, we engineered the two-component pleurotolysin (PlyAB) toxin to …
sequencing. Here, we engineered the two-component pleurotolysin (PlyAB) toxin to …
Nanopore‐based protein sequencing using biopores: Current achievements and open challenges
The synergy of life sciences discoveries, biomolecular and protein engineering advances,
and groundbreaking nanofabrication technologies, has introduced over the past years the …
and groundbreaking nanofabrication technologies, has introduced over the past years the …
Enhanced identification of Tau acetylation and phosphorylation with an engineered aerolysin nanopore
Posttranslational modifications (PTMs) affect protein function/dysfunction, playing important
roles in the occurrence and development of tauopathies including Alzheimer's disease. PTM …
roles in the occurrence and development of tauopathies including Alzheimer's disease. PTM …