More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

IL‐37 is unique in the IL‐1 family in that unlike other members of the family, IL‐37 broadly
suppresses innate immunity. IL‐37 can be elevated in humans with inflammatory and …

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two
decades has emphasized the inflammatory process as a key component in the …

There is an expanding role for interleukin (IL)-1 in diseases from gout to cancer. More than
any other cytokine family, the IL-1 family is closely linked to innate inflammatory and immune …

Heart failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, and poor
exercise capacity due to insufficient cardiac function. HF represents the leading cause of …

Иммуновоспалительные заболевания человека в зависимости от преобладающих
механизмов активации иммунитета разделяются на две основные категории …

Cartilage has a limited healing capacity; however, studies into the basic biological
characteristics, formation and structural maintenance of the cartilage collagen network are …

Inflammasome-promoted sterile inflammation following cardiac damage is critically
implicated in heart dysfunction after myocardial infarction (MI). Glycogen synthase kinase-3 …

Streptococcus pneumoniae infections can lead to severe complications with excessive
immune activation and tissue damage. Interleukin-37 (IL-37) has gained importance as a …