Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Background Whereas the exact aetiology of microscopic colitis [MC] remains unknown, a
dysregulated immune response to luminal factors or medications is the most accepted …

Aging is a broad process that occurs as a time-dependent functional decline and tissue
degeneration in living organisms. On a smaller scale, aging also exists within organs …

The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth,
chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not …

Drug repurposing has been shown to bring safe medications to new patient populations, as
recently evidenced by the COVID-19 pandemic. We investigated whether we could use …

Heparanase (HPSE) is a multitasking protein characterized by enzymatic and non-
enzymatic activities. By means of its enzymatic activity, HPSE catalyzes the cutting of the …

Acute respiratory distress syndrome (ARDS) is the most common respiratory disease in ICU.
Although there are many treatment and support methods, the mortality rate is still high. The …

Endometriosis are characterized by dense fibrous tissue. Numerous studies have
investigated roles of inflammation on the pathophysiology of endometriosis. However, the …