The epithelial-to-mesenchymal transition as a possible therapeutic target in fibrotic disorders
J Di Gregorio, I Robuffo, S Spalletta… - Frontiers in cell and …, 2020 - frontiersin.org
Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …
extracellular matrix, which leads to scarring and loss of function of the affected organ or …
The wound healing, chronic fibrosis, and cancer progression triad
B Rybinski, J Franco-Barraza… - Physiological …, 2014 - journals.physiology.org
For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …
commonalities that tumors and wounded tissues share, the process of wound healing also …
Reactive oxygen species drive epigenetic changes in radiation‐induced fibrosis
S Shrishrimal, EA Kosmacek… - … medicine and cellular …, 2019 - Wiley Online Library
Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …
Pathogenesis of microscopic colitis: a systematic review
Y Zabana, G Tontini… - Journal of Crohn's …, 2022 - academic.oup.com
Background Whereas the exact aetiology of microscopic colitis [MC] remains unknown, a
dysregulated immune response to luminal factors or medications is the most accepted …
dysregulated immune response to luminal factors or medications is the most accepted …
Phenotypic screening of 1,953 FDA-approved drugs reveals 26 hits with potential for repurposing for Peyronie's disease
Drug repurposing has been shown to bring safe medications to new patient populations, as
recently evidenced by the COVID-19 pandemic. We investigated whether we could use …
recently evidenced by the COVID-19 pandemic. We investigated whether we could use …
Heparanase and macrophage interplay in the onset of liver fibrosis
MF Secchi, M Crescenzi, V Masola, FP Russo… - Scientific Reports, 2017 - nature.com
The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth,
chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not …
chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not …
Senescence-associated cell transition and interaction (sactai): A proposed mechanism for tissue aging, repair, and degeneration
Aging is a broad process that occurs as a time-dependent functional decline and tissue
degeneration in living organisms. On a smaller scale, aging also exists within organs …
degeneration in living organisms. On a smaller scale, aging also exists within organs …
Recent data concerning heparanase: focus on fibrosis, inflammation and cancer
Heparanase (HPSE) is a multitasking protein characterized by enzymatic and non-
enzymatic activities. By means of its enzymatic activity, HPSE catalyzes the cutting of the …
enzymatic activities. By means of its enzymatic activity, HPSE catalyzes the cutting of the …
Role of heparanase in ARDS through autophagy and exosome pathway
F Feng, LJ Wang, JC Li, TT Chen, L Liu - Frontiers in Pharmacology, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is the most common respiratory disease in ICU.
Although there are many treatment and support methods, the mortality rate is still high. The …
Although there are many treatment and support methods, the mortality rate is still high. The …
Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair
J Esser-von Bieren, B Volpe, DB Sutherland… - PLoS …, 2015 - journals.plos.org
Helminth parasites can cause considerable damage when migrating through host tissues,
thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination …
thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination …