Helminth parasites can cause considerable damage when migrating through host tissues,
thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination …

Intestinal subepithelial myofibroblasts (ISMFs) are mesenchymal cells that reside in the
subepithelial region throughout the intestine. When the intestine is damaged, the migratory …

Abstract Effects of nadroparin sodium, a low molecular weight heparin, in colitis was
investigated by analyzing proteins implicated in nuclear factor E2-related factor-2/heme …

Abstract Cyclooxygenase-2 (COX-2) inhibition prevents adenoma formation in humans and
mouse models of colon cancer. The selective COX-2 inhibitor celecoxib reduces COX-2 and …

Heparanase (HPSE), a heparan sulfate-specific endo-β-D-glucuronidase, plays an
important role in tumor cell metastasis through the degradation of extracellular matrix …

Microscopic colitis (MC) has become a disease with increased awareness since new data of
the pathogenesis, diagnosis and therapy are arising. The incidence of MC is increasing …

Background: Prostate cancer (PCa) is a significant health concern throughout the world.
Standard therapy for advanced disease consists of anti-androgens, however, almost all …

The COX-2 inhibitor Celecoxib, tested in phase III trials for the prevention of sporadic colon
adenomas, reduced the appearance of new adenomas, but was unable to affect the …

We previously demonstrated that non-toxic doses of Celecoxib induced the immediate
phosphorylation of Erk1-2 in colon tumor associated fibroblasts (TAFs), increasing their …

Non-steroidal anti-inflammatory drugs prevent colorectal cancer by inhibiting
cyclooxygenase (COX) enzymes that synthesize tumor-promoting prostaglandins. 15 …