The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

[HTML][HTML] The human hypothalamus in mood disorders: the HPA axis in the center

AM Bao, DF Swaab - IBRO reports, 2019 - Elsevier
There are no specific structural neuropathological hallmarks found in the brain of mood
disorders. Instead, there are molecular, functional and structural alterations reported in many …

Does oxytocin increase trust in humans? A critical review of research

G Nave, C Camerer… - … on Psychological Science, 2015 - journals.sagepub.com
Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role
in social attachment and affiliation in nonhuman mammals. Inspired by this initial research …

Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children

DS Carson, SW Berquist, TH Trujillo, JP Garner… - Molecular …, 2015 - nature.com
The neuropeptide oxytocin (OXT) exerts anxiolytic and prosocial effects in the central
nervous system of rodents. A number of recent studies have attempted to translate these …

[HTML][HTML] Oxytocin in schizophrenia: pathophysiology and implications for future treatment

KK Goh, CH Chen, HY Lane - International journal of molecular sciences, 2021 - mdpi.com
Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal
behavior, such as social function deficits or other behaviors that are disconnected from …

Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat

BS Bentzley, TC Jhou… - Proceedings of the …, 2014 - National Acad Sciences
Development of new treatments for drug addiction will depend on high-throughput screening
in animal models. However, an addiction biomarker fit for rapid testing, and useful in both …

[HTML][HTML] The oxytocin paradox

RAI Bethlehem, S Baron-Cohen, J van Honk… - Frontiers in behavioral …, 2014 - frontiersin.org
In 2005, Kosfeld et al. published their now seminal paper showing that intranasal oxytocin
(OXT) administration increased interpersonal trust (Kosfeld et al., 2005). This finding …

Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis

JM Borland, JK Rilling, KJ Frantz… - …, 2019 - nature.com
The rewarding properties of social interactions are essential for the expression of social
behavior and the development of adaptive social relationships. Here, we review sex …

Oxytocin and autism: a systematic review of randomized controlled trials

A Preti, M Melis, S Siddi, M Vellante… - Journal of child and …, 2014 - liebertpub.com
Objective: Little is known about the effectiveness of pharmacological interventions on autism
spectrum disorder (ASD). This is a systematic review of the randomized controlled trials …

Oxytocin acts in nucleus accumbens to attenuate methamphetamine seeking and demand

BM Cox, BS Bentzley, H Regen-Tuero, RE See… - Biological …, 2017 - Elsevier
Background Evidence indicates that oxytocin, an endogenous peptide well known for its role
in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We …