Structure and function of the immune system in the spleen
SM Lewis, A Williams, SC Eisenbarth - Science immunology, 2019 - science.org
The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …
Targeting TFH cells in human diseases and vaccination: rationale and practice
The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Abstract Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell
responses in patients with cancer but PD-1 is also expressed by other immune cells …
responses in patients with cancer but PD-1 is also expressed by other immune cells …
Cytokine-skewed Tfh cells: functional consequences for B cell help
AC Olatunde, JS Hale, TJ Lamb - Trends in immunology, 2021 - cell.com
CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria
Differentiation of naïve CD4+ T cells into functionally distinct T helper (TH) subsets is crucial
for the orchestration of immune responses. Because of extensive heterogeneity and multiple …
for the orchestration of immune responses. Because of extensive heterogeneity and multiple …
The RTS, S malaria vaccine: Current impact and foundation for the future
JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …
A cytokine-independent approach to identify antigen-specific human germinal center T follicular helper cells and rare antigen-specific CD4+ T cells in blood
JM Dan, CS Lindestam Arlehamn… - The Journal of …, 2016 - journals.aai.org
Detection of Ag-specific CD4+ T cells is central to the study of many human infectious
diseases, vaccines, and autoimmune diseases. However, such cells are generally rare and …
diseases, vaccines, and autoimmune diseases. However, such cells are generally rare and …
Human T cell response to dengue virus infection
DENV is a major public health problem worldwide, thus underlining the overall significance
of the proposed Program. The four dengue virus (DENV) serotypes (1–4) cause the most …
of the proposed Program. The four dengue virus (DENV) serotypes (1–4) cause the most …