The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …

The diverse functions of proteins depend on their proper three-dimensional folding and
assembly. Misfolded cellular proteins can potentially harm cells by forming aggregates in …

The ubiquitin–proteasome system (UPS) regulates protein quality or control and plays
essential roles in several biological and biochemical processes in fungi. Here, we present …

Protein misfolding and aggregation are implicated in many neurodegenerative diseases.
One of these diseases is Huntington's, which is caused by increased glutamine-encoding …

Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …

High-level production of recombinant proteins in industrial microorganisms is often limited
by the formation of misfolded proteins or protein aggregates, which consequently induce …

Insoluble protein deposits are hallmarks of neurodegenerative disorders and common forms
of dementia. The aberrant aggregation of misfolded proteins involves a complex cascade of …

This study represents the first report comparing the acute toxicity of three types of
nanoplastics (polystyrene (PS), polypropylene (PP), and polyethylene (PE)) on multiple …

The ubiquitin-specific chaperone AAA-ATPase Cdc48 and its orthologs p97/valosin-
containing protein (VCP) in mammals play crucial roles in regulating numerous intracellular …

Valosin-containing protein (VCP) was found to play a vital protective role against cardiac
stresses. Genetic mutations of VCP are associated with human dilated cardiomyopathy …