MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …

Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies
characterized by abnormal proliferation of immature lymphoid cells. It is the most commonly …

SOX4 is a critical developmental transcription factor in vertebrates and is required for
precise differentiation and proliferation in multiple tissues. In addition, SOX4 is …

Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL
or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an …

Mixed lineage leukemia (MLL) gene rearrangements are associated with acute leukemia.
The protein menin is regarded as a critical oncogenic cofactor of the resulting MLL fusion …

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease
accounting for 15–20% of all childhood acute leukemias, while it is responsible for more …

Acute promyelocytic leukemia (APL) is characterized by t (15; 17)(q22; q21), resulting in a
PML-RARA fusion that is the master driver of APL. A few cases that cannot be identified with …

The association between tobacco smoke and acute myeloid leukemia (AML) is well
established in adults but not in children. Individual-level data on parental cigarette smoking …

KMT2 (histone-lysine N-methyltransferase subclass 2) complexes methylate lysine 4 on the
histone H3 tail at gene promoters and gene enhancers and, thus, control the process of …